Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04?
Organic & Biomolecular Chemistry Pub Date: 2019-02-14 DOI: 10.1039/C9OB00198K
Abstract
The marilones and marilines are a new family of polyketide metabolites recently isolated from the marine-derived fungus Stachylidium sp. 293K04. They are characterized by a phthalide and phthalimidine skeleton, respectively. From a series of feeding experiments using 13C-labeled precursors we could outline the biogenetic origin of the basic carbon skeleton of marilone A and mariline B. Results established the tetraketide nature of the phthalide/phthalimidine nucleus including the involvement of a methylated acetate starter unit in polyketide biosynthesis, which is unique amongst fungal metabolites.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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