Aqueous formic acid: an efficient, inexpensive and environmentally friendly organocatalyst for three-component Strecker synthesis of α-aminonitriles and imines with excellent yields
RSC Advances Pub Date: 2014-10-29 DOI: 10.1039/C4RA11957F
Abstract
Aqueous formic acid (37%) which is an efficient, inexpensive and environmentally friendly organocatalyst was used in the Strecker reaction to afford α-aminonitriles and imines. Reaction was carried out under mild conditions and room temperature in high yields. We obtained α-aminonitrile derives by using trimethylsilyl cyanide through the Strecker reaction. The most important feature of formic acid as a catalyst is affordability and availability.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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