Solution-phase synthesis of chiral O-acyl isodipeptides?

MedChemComm Pub Date: 2011-09-14 DOI: 10.1039/C1MD00130B

Abstract

O-Acylation of N-Boc-protected-serine and -threonine with N-Pg-(α-aminoacyl)benzotriazoles afforded the chiral O-acylated isodipeptides at 23 °C in yields of 74–91%.

Graphical abstract: Solution-phase synthesis of chiral O-acyl isodipeptides
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