Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors??

MedChemComm Pub Date: 2011-10-20 DOI: 10.1039/C1MD00203A

Abstract

A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest.

Graphical abstract: Click JAHAs: conformationally restricted ferrocene -based histone deacetylase inhibitors
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