Simplified platensimycin analogues as antibacterial agents?

MedChemComm Pub Date: 2011-11-30 DOI: 10.1039/C2MD00252C

Abstract

A series of substituted 2-hydroxybenzoic acid derivatives were synthesized as simplified analogues of platensimycin. The final compounds were evaluated against the Gram-positive bacteria, methicillin-resistant Staphylococcus aureus. Analogues that possessed polycyclic groups directly attached to the substituted benzoic acid were able to demonstrate modest antimicrobial activity.

Graphical abstract: Simplified platensimycin analogues as antibacterial agents
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