Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells?

MedChemComm Pub Date: 2012-06-12 DOI: 10.1039/C2MD20047C

Abstract

Interesting selectivities for cancer stem cells versus neuronal stem cells are demonstrated in vitro with analogues of canthin-6-one, an indolic alkaloid isolated from Zanthoxylum chiloperone var. angustifolium (Rutaceae). The implication of the PI3/AKT signalling pathway is also disclosed.

Graphical abstract: Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells
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