Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity?
MedChemComm Pub Date: 2012-09-21 DOI: 10.1039/C2MD20134H
Abstract
New YC-1 derivatives were synthesized and evaluated with HIF-1 transcriptional activity, and a potent derivative shows activity in vivo. Furthermore, for the mechanistic study of the YC-1 derivative, we evaluate the antiproliferative activity against 39 human cancer cell lines and the localization of active probes in cells.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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