The structure–activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface?

MedChemComm Pub Date: 2013-09-17 DOI: 10.1039/C3MD00197K

Abstract

We recently reported the discovery of UNC1215, a potent and selective chemical probe for the L3MBTL3 methyllysine reader domain. In this article, we describe the development of structure–activity relationships (SAR) of a second series of potent L3MBTL3 antagonists which evolved from the structure of the chemical probe UNC1215. These compounds are selective for L3MBTL3 against a panel of methyllysine reader proteins, particularly the related MBT family proteins, L3MBTL1 and MBTD1. A co-crystal structure of L3MBTL3 and one of the most potent compounds suggests that the L3MBTL3 dimer rotates about the dimer interface to accommodate ligand binding.

Graphical abstract: The structure–activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface
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