ω-Heteroarylalkylcarbamates as inhibitors of fatty acid amide hydrolase (FAAH)?
MedChemComm Pub Date: 2014-05-16 DOI: 10.1039/C4MD00181H
Abstract
Fatty acid amide hydrolase (FAAH) is a serine hydrolase that terminates the analgetic and anti-inflammatory effects of endocannabinoids such as anandamide. Herein we describe structure–activity relationship studies on a new series of ω-heteroarylalkylcarbamate inhibitors of FAAH. The most active compounds exhibit IC50 values in the low nanomolar range. Investigations on selectivity and metabolic stability of these inhibitors are also presented.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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