Multifunctional dendrimers modified with alpha-tocopheryl succinate for targeted cancer therapy?
MedChemComm Pub Date: 2014-01-29 DOI: 10.1039/C3MD00324H
Abstract
Generation 5 poly(amidoamine) dendrimers were used as a nanoplatform to conjugate covalently an anticancer drug, alpha-tocopheryl succinate (α-Tos) and targeting ligand folic acid (FA). The formed multifunctional dendrimers are able to endow the hydrophobic drug α-Tos with improved water solubility for targeted inhibition of cancer cells via an FA receptor-mediated targeting pathway.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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