Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants?
MedChemComm Pub Date: 2015-09-30 DOI: 10.1039/C5MD00353A
Abstract
A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containing an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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