A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1??
MedChemComm Pub Date: 2016-03-15 DOI: 10.1039/C5MD00575B
Abstract
The mammalian proton-coupled oligopeptide transporter PepT1 is recognised as an important route of oral drug delivery. Peptide-based compounds offer great potential as drugs but their application is limited by poor membrane permeability, amongst other challenges. Using cyclosporin A as a proof-of-concept, we demonstrate for the first time that peptidic molecules over 1000 Da in size can be targeted towards and transported by PepT1.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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