Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists??
MedChemComm Pub Date: 2017-03-15 DOI: 10.1039/C7MD00058H
Abstract
Using the pharmacophore-based virtual screening platform ANCHOR.QUERY, we morphed our recently described Ugi-4CR scaffold towards a β-lactam scaffold with potent p53-MDM2 antagonizing activities. 2D-HSQC and FP measurements confirm potent MDM2 binding. Molecular modeling studies were used to understand the observed SAR in the β-lactam series.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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