Efficient copper-catalyzed amination of DNA-conjugated aryl iodides under mild aqueous conditions?
MedChemComm Pub Date: 2018-05-17 DOI: 10.1039/C8MD00185E
Abstract
Herein, we describe the development of copper-catalyzed cross-coupling of DNA-conjugated aryl iodides with aliphatic amines. This protocol leverages a novel ligand, 2-((2,6-dimethoxyphenyl)amino)-2-oxoacetic acid, to effect the transformation in aqueous DMSO, under mild conditions and in air, making it an ideal candidate for the synthesis of DNA-encoded libraries.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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