Synthesis of novel perillyl–dihydropyrimidinone hybrids designed for antiproliferative activity?
MedChemComm Pub Date: 2018-07-31 DOI: 10.1039/C8MD00270C
Abstract
A series of fifteen novel dihydropyrimidinone hybrid compounds were synthesized in good yields via a multicomponent reaction combined with the Huisgen reaction. The antiproliferative activity was investigated against nine tumor cell lines, and four hybrid compounds (TGI < 10 μM) showed promising antiproliferative activity against the tumor cell lines OVCAR-3 (ovarian), UACC-62 (melanoma) and U251 (glioma). Several hybrid compounds assayed have high TGI values (TGI 147.92–507.82) for the human keratinocyte cell line (HaCat), which reveals selectivity to cancer cells.
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Journal Name：MedChemComm
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CAS no.: 89640-58-4
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