Application of a sensitive liquid chromatography-mass spectrometry method to a pharmacokinetic study of nerolidol in rat plasma
Analytical Methods Pub Date: 2015-12-09 DOI: 10.1039/C5AY02575C
Abstract
Nerolidol is a dominant volatile compound isolated from Oplopanax horridus. A liquid chromatography-electrospray ionization-mass spectrometry (LC-MS) method was used to evaluate the pharmacokinetics of nerolidol in rats. A series of extraction and concentration methods were optimized for the extraction efficiency of biosamples. Chromatographic separation was performed on a reverse LC column within a total run time of 14.5 min. This method was linear over 10–10?000 ng mL?1 and the limit of quantification for nerolidol was 10 ng mL?1, with both inter-day and intra-day (CV) precision < 8% and accuracy (RE) ranging from ?6% to 6%. RE for nerolidol nerolidol was lower than 11% after 4 h and 16% after 27 h freeze–thaw cycles, indicating the samples were stable in the analysis conditions.
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Journal Name：Analytical Methods
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CAS no.: 89640-58-4
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