Delayed release singlet oxygen sensitizers based on pyridone-appended porphyrins?
Photochemical & Photobiological Sciences Pub Date: 2017-08-22 DOI: 10.1039/C7PP00244K
Abstract
A new type of porphyrin photosensitizer capable of generating singlet oxygen upon irradiation, storing it through binding to pyridone subunits, followed by slow release at 20–40 °C, is reported. The timescale of singlet oxygen release can be varied depending on the pyridone group substitution pattern, forming endoperoxides of different stabilities. Modified tetra- and octa-substituted pyridone-porphyrins showed solubility in water, allowing for straightforward delivery into cells. The effect of delayed singlet oxygen formation due to endoperoxide decomposition was demonstrated on cancer cells in vitro.
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Journal Name：Photochemical & Photobiological Sciences
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CAS no.: 89640-58-4
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