Synthesis and photodynamic effects of new porphyrin/4-oxoquinoline derivatives in the inactivation of S. aureus
Photochemical & Photobiological Sciences Pub Date: 2019-07-09 DOI: 10.1039/C9PP00102F
Abstract
New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a β-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a–e. Singlet oxygen studies have demonstrated that all the porphyrin/4-oxoquinoline conjugates 9a–e were capable of producing cytotoxic species and found to be excellent photosensitizing agents in the inactivation of S. aureus by the antimicrobial photodynamic therapy (aPDT) protocol.
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Journal Name：Photochemical & Photobiological Sciences
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CAS no.: 89640-58-4
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