Acid cleavable PEG-lipids for applications in a ternary gene delivery vector??

Molecular BioSystems Pub Date: 2008-04-15 DOI: 10.1039/B719782A

Abstract

A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.

Graphical abstract: Acid cleavable PEG-lipids for applications in a ternary gene delivery vector
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