Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae?
Molecular BioSystems Pub Date: 2016-03-18 DOI: 10.1039/C5MB00888C
Abstract
We report for the first time that 5-hydroxytryptophan can be synthesized in Saccharomyces cerevisiae by heterologously expressing prokaryotic phenylalanine 4-hydroxylase or eukaryotic tryptophan 3/5-hydroxylase, together with enhanced synthesis of MH4 or BH4 cofactors. The innate DFR1 gene in the folate synthesis pathway was found to play pivotal roles in 5-hydroxytryptophan synthesis.
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Journal Name：Molecular BioSystems
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CAS no.: 89640-58-4
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