Peptide bond cleavage in the presence of Ni-containing particles?

Metallomics Pub Date: 2020-04-29 DOI: 10.1039/D0MT00070A

Abstract

NiO nanoparticles and non-stoichiometric black NiO were shown to be effective sources of Ni2+ ions causing sequence-selective peptide bond hydrolysis. NiO nanoparticles were as effective in this reaction as their molar equivalent of soluble Ni(II) salt. These findings highlight the efficacy of delivery of toxic Ni2+ by these environmentally available particles.

Graphical abstract: Peptide bond cleavage in the presence of Ni-containing particles
Recommended Literature