The differing reactivity of the bromo and nitro groups in 4-bromo-5-nitrophthalonitrile towards nucleophilic attack

Mendeleev Communications Pub Date: DOI: 10.1070/MC2000v010n02ABEH001147

Abstract

The high reactivity of 4-bromo-5-nitrophthalonitrile and different mobilities of the leaving groups (bromo and nitro) in aromatic nucleophilic substitution reactions offer new opportunities for the synthesis of substituted phthalonitriles and then various hetero-cyclic compounds.

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