The ortho : para ratio in aromatic nucleophilic substitution

Journal of the Chemical Society D: Chemical Communications Pub Date: DOI: 10.1039/C29710000069

Abstract

Summary p-Nitrofluorobenzene reacts slightly faster than o-nitrofluorobenzene with methoxide ions in methanol, but under the same conditions the 2-fluorine atom in 2,4-difluoronitrobenzene is replaced faster than the 4-fluorine atom; an explanation is given to reconcile these observations.

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