Alternative syntheses of 1-, 2-, and 3-O-methyl-D-mannitol

Journal of the Chemical Society C: Organic Pub Date: DOI: 10.1039/J39670000114

Abstract

1-O-Methyl-D-mannitol has been prepared by treating 1,2-anhydro-3,4:5,6-di-O-isopropylidene-D-mannitol with sodium methoxide. 2-O-Methyl-D-mannitol has been obtained by stepwise hydrolysis of 1,2,6-tri-O-benzoyl-3,4-O-isopropylidene-D-mannitol, and 3-O-methyl-D-mannitol has been isolated after reduction of 3-O-methyl-D-fructose with Raney nickel.

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