Phosphoryl transfer promoted by nitriles in the presence of highly reactive halides
Journal of the Chemical Society C: Organic Pub Date: DOI: 10.1039/J39690000074
Abstract
Nitriles, e.g. acetonitrile and benzonitrile slowly react at elevated temperatures with mono-substituted phosphoric acids to give sym-pyrophosphates. Prior addition of a highly reactive halide, e.g. a chloromethyl ether or thioether, gives rise to a much more effective phosphoryl transfer. Both anhydrides and esters can be generated in this way.
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Journal Name：Journal of the Chemical Society C: Organic
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CAS no.: 89640-58-4
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