A total synthesis of isoliensinine
Journal of the Chemical Society C: Organic Pub Date: DOI: 10.1039/J39690000298
Abstract
Cyclisation of the amide (VI) prepared by condensation of 4-methoxyphenylacetic acid and 4-benzyloxy-3-methoxyphenethylamine, gave the 3,4-dihydroisoquinoline (VII), the methiodide of which, on reduction, afforded the tetrahydroisoquinoline (IX). Ullmann reaction between (±)-(X) and (±)-(XI) afforded a mixture of the diastereoisomeric racemates of OO-dibenzylisoliensinine (V), the debenzylation of which gave a mixture of diastereoisomeric racemates of isoliensinine (II). Finally, total synthesis of optical active isoliensinine has been achieved.
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Journal Name：Journal of the Chemical Society C: Organic
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CAS no.: 89640-58-4
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