4-Substituted nicotinic acids and nicotinamides. Part III. Preparation of 4-methylnicotinic acid riboside
Journal of the Chemical Society C: Organic Pub Date: DOI: 10.1039/J39690000918
Abstract
A method for the synthesis of nicotinic acid ribosides is described. The stepwise reaction between the tetra-n-butylammonium salt of nicotinic acid and 3,5-di-O-benzoyl-β-D-ribofuranosyl chloride gives 1-O-nicotinoyl-3,5-di-O-benzoyl-D-ribofuranose and 1-(3,5-di-O-benzoyl-D-ribofuranosyl)-3-(3,5-di-O-benzoyl-D-ribofuranosyloxycarbonyl)pyridinium chloride. The riboside obtained by stepwise hydrolysis of the quaternary derivative was essentially the β-anomer. 4-Methylnicotinic acid derivatives were similarly obtained.
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Journal Name：Journal of the Chemical Society C: Organic
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CAS no.: 89640-58-4
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