A catalyst- and solvent-free thermal multicomponent approach for the construction of diverse and polysubstituted 2-aminopyridines and their antibacterial activity?
Organic & Biomolecular Chemistry Pub Date: 2016-10-11 DOI: 10.1039/C6OB02015A
Abstract
A highly efficient and facile thermal multicomponent cascade reaction of readily available 4-oxo-4H-chromene-3-carbaldehydes with cyanoacetates or cyanoamides and anilines or aliphatic amines under solvent and catalyst-free conditions was developed for the synthesis of a range of polysubstituted 2-aminopyridine derivatives in good to excellent yield. This protocol proceeds via a cascade reaction of Knoevenagel condensation, nucleophilic addition, intramolecular Michael addition, and ring opening. As an application of this methodology, the antibacterial activities of some of the synthetic compounds were evaluated.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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