Binaphthyl-based chiral ligands: design, synthesis and evaluation of their performance in enantioselective addition of diethylzinc to aromatic aldehydes?
Organic & Biomolecular Chemistry Pub Date: 2020-11-18 DOI: 10.1039/D0OB02127J
Abstract
The design strategy and the performance of binaphthyl-based chiral ligands were evaluated with computation and enantioselective addition of diethylzinc to aromatic aldehydes. Under optimized conditions, enantioselective addition of diethylzinc to aromatic aldehydes provided the desired optically active secondary alcohols in high isolated yields (up to 91%) and excellent enantiomeric excesses (up to 98% ee).
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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