On the Synthesis of 2-Amino-4,6-difluorobenzonitrile: Highly Selective Formation of 5-Fluoro-3-nitro-1,2-benzoquinone 2-Diazide in the Attempted Sandmeyer Cyanation of 2,4-Difluoro-6-nitrobenzenediazonium Cation?
Journal of Chemical Research, Synopses Pub Date: DOI: 10.1039/A707205H
Abstract
Attempted cyanation of a diazonium salt derived from 2,4-difluoro-6-nitroaniline gives 5-fluoro-3-nitro-1,2-benzoquinone 2-diazide? in good yield by selective nucleophilic substitution of the 2-fluoride group by hydroxide, instead of the desired 2-amino-4,6-difluorobenzonitrile, which can be obtained by the reaction of 2,4,6-trifluorobenzonitrile with ammonia.
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Journal Name：Journal of Chemical Research, Synopses
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CAS no.: 89640-58-4
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