A perfect double role of CF3 groups in activating substrates and stabilizing adducts: the chiral Br?nsted acid-catalyzed direct arylation of trifluoromethylketones?

Chemical Communications Pub Date: 2009-03-09 DOI: 10.1039/B900474B

Abstract

A direct and efficient Br?nsted acid-promoted arylation of tri- and difluoromethyl ketones, as well perfluoroalkyl ketones, has been developed; good to excellent enantioselectivities (up to 99% ee) were achieved.

Graphical abstract: A perfect double role of CF3 groups in activating substrates and stabilizing adducts: the chiral Br?nsted acid-catalyzed direct arylation of trifluoromethylketones
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