Mild and highly efficient metal-free oxidative α-cyanation of N-acyl/sulfonyl tetrahydroisoquinolines?
RSC Advances Pub Date: 2014-11-05 DOI: 10.1039/C4RA12922A
Abstract
A highly efficient metal-free oxidative α-cyanation reaction of N-acyl/sulfonyl tetrahydroisoquinolines under mild conditions was developed. The reaction uses 2,2,6,6-tetramethylpiperidine N-oxide fluoroborate salt (T+BF4?) as the oxidant and trimethylsilyl cyanide as the source of the cyano group.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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