Box–Behnken designed adsorption based elution – unique separation process for commercially important acetyl shikonin from Arnebia nobilis?

RSC Advances Pub Date: 2014-12-16 DOI: 10.1039/C4RA13570A

Abstract

Acetyl shikonin (AS), a pharmaceutically and commercially important compound, is a minor constituent in the industrial crop Arnebia nobilis. A Box–Behnken optimized, robust separation technique for AS was established by an adsorption based elution method. Optimized yields depict an increase of 78.9% total recovery of AS (97.8% pure), compared to conventional chromatography.

Graphical abstract: Box–Behnken designed adsorption based elution – unique separation process for commercially important acetyl shikonin from Arnebia nobilis
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