Unprecedented one-pot multicomponent synthesis of propargylamines using Amberlyst A-21 supported CuI under solvent-free conditions?
RSC Advances Pub Date: 2015-05-15 DOI: 10.1039/C5RA05546F
Abstract
Amberlyst A-21 supported CuI was found to be a highly efficient novel heterogeneous catalyst for the three-component reaction between amines, aldehydes and alkynes, commonly called A3-coupling. An environmentally benign, one-pot, A3-coupling reaction of various aldehydes, amines and terminal alkynes for the synthesis of propargylamine derivatives is here described. The developed protocol avoids the use of solvent and produces a variety of propargylamines in excellent yields within short reaction times. The catalyst can be easily prepared, recovered and reused for several times, without any appreciable loss in its activity.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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