A catalytic and iterative route to β-substituted estersvia highly enantioselective conjugate addition of dimethylzinc to unsaturated malonates?

Chemical Communications Pub Date: 2004-02-24 DOI: 10.1039/B315871C

Abstract

Using the chiral phosphoramidite ligand (S,R,R)-L1 in the conjugate addition of dimethylzinc to acyclic unsaturated malonates, enantioselectivities of up to 98% have been obtained for the first time. An iterative and stereodivergent route to 3,5-dimethyl esters that takes advantage of this asymmetric catalysis has been developed.

Graphical abstract: A catalytic and iterative route to β-substituted esters via highly enantioselective conjugate addition of dimethylzinc to unsaturated malonates
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