One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine?
Green Chemistry Pub Date: 2014-12-18 DOI: 10.1039/C4GC02325K
Abstract
We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and norcoclaurine synthase (NCS) in a one-pot, one-substrate ‘triangular’ cascade. Employment of up to two C–C bond forming steps allows for the rapid generation of molecular complexity under mild conditions.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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