Impact of aza-substitutions on the preference of helix handedness for β-peptide oligomers: a DFT study?
RSC Advances Pub Date: 2023-01-19 DOI: 10.1039/D2RA07575J
Abstract
We studied the helix preference of the heterochiral pentamers of cis-2-aminocyclohexanecarboxylic acid (c-ACHC) and cis-2-aminocyclopentanecarboxylic acid (c-ACPC) with alternating backbone configurations by replacing Cβ-aza- or Cα-aza-peptide residues using DFT methods in solution. The helix-handedness preferences of two pentamers were strongly affected by the replacement positions (i.e., chiralities) but not depending on the solvent polarity.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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