Synthesis and photophysical characterization of fluorescent indole nucleoside analogues?
RSC Advances Pub Date: 2023-05-31 DOI: 10.1039/D3RA03457G
Abstract
Fluorescent nucleosides are useful chemical tools for biochemical research and are frequently incorporated into nucleic acids for a variety of applications. The most widely utilized fluorescent nucleoside is 2-aminopurine-2′-deoxyribonucleoside (2APN). However, 2APN is limited by a moderate Stokes shift, molar extinction coefficient, and quantum yield. We recently reported 4-cyanoindole-2′-deoxyribonucleoside (4CIN), which offers superior photophysical characteristics in comparison to 2APN. To further improve upon 4CIN, a focused library of additional analogues combining the structural features of 2APN and 4CIN were synthesized and their photophysical properties were quantified. Nucleosides 2–6 were found to possess diverse photophysical properties with some features superior to 4CIN. In addition, the structure–function relationship data gained from 1–6 can inform the design of next-generation fluorescent indole nucleosides.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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