Diels–Alder adducts of a labdane diterpenoid from the Chinese liverwort Pallavicinia subciliata?
Organic Chemistry Frontiers Pub Date: 2022-02-22 DOI: 10.1039/D1QO01891D
Abstract
A 7,8-seco-2,8-cyclolabdane diterpenoid, pallasubcin A (1), and three rare pallasubcin A-derived dimers, pallasubcins B–D (2–4), formed via a Diels–Alder reaction between C-12–C-14′ and C-15–C-15′ were isolated from the Chinese liverwort Pallavicinia subciliata. Their structures were elucidated by comprehensive spectroscopic analysis, X-ray single crystal diffraction, and ECD calculations. Plausible biogenetic pathways are presented for all compounds. Preliminary anti-inflammatory determinations showed that compound 2 exhibited strong activity under nontoxic concentrations with a 73.03% (25 μM) maximum inhibition rate of NO production on LPS-induced RAW 264.7 murine macrophages.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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