Visible-light-driven photoredox-catalyzed C(sp3)–C(sp3) cross-coupling of N-arylamines with cycloketone oxime esters?

Organic Chemistry Frontiers Pub Date: 2022-03-24 DOI: 10.1039/D2QO00128D

Abstract

A novel photoredox-catalyzed C(sp3)–C(sp3) cross-coupling between N-arylamines and cycloketone oxime esters under mild conditions has been accomplished. The redox-neutral reaction proceeds with good functional group tolerance and excellent regioselectivity without any extra base or ligand control. In addition, this approach was successfully applied for the late-stage modification of short peptides and analogues.

Graphical abstract: Visible-light-driven photoredox-catalyzed C(sp3)–C(sp3) cross-coupling of N-arylamines with cycloketone oxime esters
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