Thermo-induced decarboxylative α-C(sp3)–H fluoroalkylation of glycine derivatives with fluorinated peroxy esters?
Organic Chemistry Frontiers Pub Date: 2022-05-11 DOI: 10.1039/D2QO00613H
Abstract
A thermo-induced decarboxylative α-C(sp3)–H fluoroalkylation of glycine derivatives with fluorinated peroxy esters was described. This protocol features transition metal free and redox-neutral conditions, broad substrate scope and excellent functional group tolerance, offering a straightforward route to the fluorinated α-amino acid derivatives in good to excellent yields. Additionally, this strategy was also applicable to the non-fluorinated α-amino acids synthesis.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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