Tandem C–N coupling/Boulton–Katritzky rearrangement reactions of 3-aminoisoxazoles or 1,2,4-oxadiazol-3-amines with 2-pyridyl trifluoromethanesulfonate: a rapid access to [1,2,4]triazolo[1,5-a]pyridines?
Organic Chemistry Frontiers Pub Date: 2022-05-17 DOI: 10.1039/D2QO00514J
Abstract
An efficient and convenient synthesis of functionalized [1,2,4]triazolo[1,5-a]pyridine derivatives is presented. The protocol involves a palladium catalyzed tandem C–N coupling/Boulton–Katritzky rearrangement process of 3-aminoisoxazoles or 1,2,4-oxadiazol-3-amines with 2-pyridyl trifluoromethanesulfonate. This protocol features readily available starting materials and could also be applied to the synthesis of leishmania CRK3 inhibitors.
![Graphical abstract: Tandem C–N coupling/Boulton–Katritzky rearrangement reactions of 3-aminoisoxazoles or 1,2,4-oxadiazol-3-amines with 2-pyridyl trifluoromethanesulfonate: a rapid access to [1,2,4]triazolo[1,5-a]pyridines](http://scimg.chem960.com/usr/1/D2QO00514J.jpg)
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Journal Name：Organic Chemistry Frontiers
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