Accessing chiral 2,2-disubstituted morpholines via organocatalytic enantioselective chlorocycloetherification?
Organic Chemistry Frontiers Pub Date: 2022-06-25 DOI: 10.1039/D2QO00390B
Abstract
Chiral morpholine is an important scaffold in organic synthesis and a pharmacophore in medicinal chemistry. However, catalytic enantioselective procedures for the construction of morpholines remain sparse. We report herein a catalytic asymmetric halocyclization protocol to furnish morpholines containing a quaternary stereocenter using cinchona alkaloid-derived phthalazine as the catalyst. Various chlorinated 2,2-disubstituted morpholines are achieved from alkenol substrates in excellent yields and enantioselectivities under mild conditions.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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