Carboxylic acid-assisted sterically demanding reductive cross-coupling between cycloalkenyl and alkyl bromides?
Organic Chemistry Frontiers Pub Date: 2023-03-10 DOI: 10.1039/D3QO00155E
Abstract
A nickel-catalysed reductive cross-coupling reaction between 2-bromo cycloalkenyl carboxylic acids and alkyl bromides has been developed, affording all-carbon tetrasubstituted cycloalkenes in moderate to excellent yields up to 92%. Mechanistic studies indicated that the carboxylic acid group plays an important assisting role in this sterically demanding coupling reaction.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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