Copper-mediated three-component synthesis of 2-trifluoromethyl benzimidazoles?
Organic Chemistry Frontiers Pub Date: 2022-04-28 DOI: 10.1039/D2QO00285J
Abstract
A copper-mediated three-component reaction of o-iodoanilines, anilines, and ethyl trifluoropyruvate is reported. The transformation allows diverse substrate scope on both o-iodoanilines and anilines, delivering various 2-trifluoromethylbenzimidazole products in moderate to good yields. Mechanistic studies suggest that this transformation proceeds via condensation of o-iodoaniline with ethyl trifluoropyruvate, followed by an intermolecular Ullmann-type cross-coupling reaction with aniline and intramolecular amination.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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