SO2ClF-promoted chlorination-oxidation of 2-methylindoles: a one-step synthetic method to access 2,3-difunctionalized indoles?
Organic Chemistry Frontiers Pub Date: 2023-07-11 DOI: 10.1039/D3QO00879G
Abstract
A direct and one-step method for the synthesis of 3-chloro-2-formylindoles with SO2ClF is reported. This tandem system consists of double electrophilic chlorination and deprotonation, nucleophilic addition of H2O to the resulting enamine intermediate, and subsequent oxidation. Various readily available 2-methylindoles were applicable to this protocol under mild conditions, furnishing 2,3-difunctionalized indoles in good to high yields.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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