Total synthesis of (±) commiphoranes C–D and their epimers?

Organic & Biomolecular Chemistry Pub Date: 2022-02-21 DOI: 10.1039/D2OB00158F

Abstract

(±) Commiphorane C, (±) commiphorane D, and their two isomers were synthesized through a linear synthesis strategy in 14 steps. Key features of the strategy include the construction of the relative configurations of C-5 and C-6 via aldehyde crotylation followed by the Mitsunobu reaction and ring A via an intramolecular Aldol reaction. The biological evaluation revealed that (±) commiphorane C and (±) isomer-1 significantly attenuated the overproduction of fibronectin, collagen I, and α-SMA in TGF-β1-induced rat renal proximal tubular cells. Intermediate (±) 11 significantly decrease the overexpression of collagen I. Cytotoxicity studies showed that 1a–1d and (±) 11 were not toxic to NRK-52E cells.

Graphical abstract: Total synthesis of (±) commiphoranes C–D and their epimers
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