Enantioselective catalytic Povarov reactions

Organic & Biomolecular Chemistry Pub Date: 2021-12-21 DOI: 10.1039/D1OB02270A

Abstract

Catalytic asymmetric Povarov protocols have undergone an explosive growth, especially in the last ten years, since the first example was published in 1996. The use of chiral Lewis and Br?nsted acids and dual strategies based on their combination with catalysts acting by hydrogen bond formation, as well as covalent aminocatalysis, are reviewed. More recent variations such as the nitroso Povarov reaction and interrupted Povarov reactions as a route to chiral scaffolds other than tetrahydroquinolines are also discussed.

Graphical abstract: Enantioselective catalytic Povarov reactions
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