A concise synthesis of herbertenolide?
Organic & Biomolecular Chemistry Pub Date: 2022-02-19 DOI: 10.1039/D2OB00041E
Abstract
A concise synthesis of (±)-herbertenolide has been accomplished herein. The strategy relies on a H2O2-mediated oxidative ring contraction of all-substituted cyclic α-formyl ketones for the stereospecific construction of contiguous quaternary carbon centers (CQCCs). Furthermore, a Sc(OTf)3/chiral N,N′-dioxide catalyzed asymmetric Michael addition of benzofuranone to MVK has been optimized for forging a chiral aromatic quaternary carbon center, which enables the formal synthesis of (+)-ent-herbertenolide.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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