Recent syntheses and biological profiling of quassinoids

Organic & Biomolecular Chemistry Pub Date: 2022-04-28 DOI: 10.1039/D2OB00490A

Abstract

Quassinoid natural products have gained considerable recognition for their diverse biological properties and their synthetically challenging, highly oxygenated polycyclic structures. Herein, we discuss strategies and tactics in the total synthesis of quassinoids that have been evolving over the past 15 years. Additionally, recent structure–activity relationships and potential biological mechanisms of actions are briefly summarized.

Graphical abstract: Recent syntheses and biological profiling of quassinoids
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